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Ivermectin is routinely used to control parasitic worms in the gastrointestinal tract of
ruminant
animals. These parasites normally enter the animal when it is grazing, pass the bowel, and set and mature in the intestines, after which they produce eggs that leave the animal via its droppings and can infest new pastures. Ivermectin is effective in killing some, but not all, of these parasites.In dogs it is routinely used as prophylaxis against
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heartworm.
This product has a selective inhibitory effect, by binding to the high affinity of chloride channels with glutamate as the valve in nerve cells and muscle cells of spinless animals, which leads to the increase of permeability of cell membranes to chloride ions, causes hyperpolarization of nerve cells or muscle cells, and causes paralysis or death of parasites. It also interacts with chloride channels of other ligand valves, such as the neurotransmitter g-aminobutyric acid (GABA). The selectivity of this product is because some mammals do not have glutamate-chloride channels in vivo, and avermectin has only low affinity for mammalian ligand-chloride channels. This product cannot penetrate the human blood-brain barrier. Onchocerciasis and strongyloidiasis and hookworm, ascaris, Trichuris trichiura, and Enterobius vermicularis infections.
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